Taking Advantage of Membranes in Controlling Drug Initial Burst Release of Sustained Release Drug Delivery/Microspheres
Paper ID : 1192-MST2015-FULL
Milad Jafari-Nodoushan1, Jalal Barzin *2, Hamid Mobedi3
1Novel Drug Delivery Systems Department, Iran Polymer and Petrochemical Institute, P.O. Box 14965/115, Tehran, Iran
2Biomaterials Department, Iran Polymer and Petrochemical Institute, P.O. Box 14965/115, Tehran, Iran
3Iran Polymer and Petrochemical Institute
Key issues in the developing of drug delivery systems are the prevention of initial burst release (IBR) and the achievement of controlled, in vivo release profiles over the releasing period of the depot. In this regard, polymeric membrane-based delivery systems play a vital role in drug administration systems, finding use in a range of applications from injectable and implantable systems to tablet and coated systems. The membrane may function primarily as a diffusive barrier, or the drug may be intimately encapsulated in the membrane structure. All of these systems have in common the formation of a membrane carrier by the process known as phase inversion.
Among many devices have been used for controlled release drug delivery, biodegradable polymer microspheres are one of the most common types. One disadvantage is associated with microspheres is their high IBR. In this study morphine containing microspheres was prepared by electrospray method. Then the microspheres subjected to in vitro drug release study. The formulations have a relatively high IBR which followed by a lower dose of drug release. For prepared morphine microspheres, a high IBR is observed which is not desirable due to its adverse effect on patient and causing respiratory problems, although this IBR are followed by a low amount of released drug in following days which would not be in therapeutic window and consequently would not be effective in pain reliving. In next step, the morphine microspheres were imbedded in an in situ-forming drug delivery system. This injectable implant was subjected to in vitro release study. The results showed that combined morphine delivery system not only decreases the IBR into an acceptable limit but also enhances the following release rate and brings it into therapeutic window which is favorable for pain reliving.
Membrane formation, Drug Delivery, Microsphere, In situ forming, Morphine
Status : Paper Accepted (Poster Presentation)