Design and characterization of PGS:PCL/Gelatin core-shell nanofibers for treatment of retinal injuries.
Paper ID : 1390-MST2015-FULL
afsaneh nadim *1, maryam masoudirad2, Shahla Khalili3
1isfahan university of tecnology
2Isfahan university of technology
3Department of Chemical Engineering, Isfahan University of Technology
Introduction and Purpose:
Today one of the newest ways to repair damaged tissues of the body is replacing it with an artificial tissues or cell scaffolds. Cell transplantation may be one of the most promising approaches of retinal repair. Various artificial membranes have been used as scaffolds for retinal pigment epithelium cells (RPE) for monolayer reconstruction. Electrospinning technique has been widely used as a simple method in fabricating highly porous micro- and nano fibrous scaffolds.
Materials and Methods:
In this study, the core-shell nanofibers of poly(glycerol sebacate), poly(caprolactone) and gelatin were successfully fabricated by coaxial electrospinning. The PGS:PCL/Gelatin core-shell fibers and PGS/PCL nanofibers were characterized by scanning electron microscopy (SEM), fourier transform infrared spectroscopy (FTIR), contact angle and tensile testing to analyze fibers morphology, wettability and mechanical properties of the scaffolds.
The results of Mechanical properties and degradation rate of scaffolds show PGS:PCL/Gelatin core-shell fibers may serve as a suitable potential for the regeneration of retinal injuries and other soft tissues.
PGS:PCL/gelatin fibers ,coaxial electrospinning, retinal scaffold.
Status : Paper Accepted (Poster Presentation)